Plated Exosome Skincare - Platelet-Derived Renewosome Serums by RION

Why Plated Is One of Dr. Piazza's Best-Selling Exosome Systems

Plated uses platelet-derived exosomes (Renewosome™) developed by Rion Aesthetics, a company founded by Mayo Clinic–affiliated regenerative medicine physicians. These extracellular vesicles are formulated into elegant, fast-absorbing serums built for redness, texture, and tone — and it's consistently one of the top-performing lines in the practice.

The Platelet-Derived Advantage

Unlike single-active serums, Plated's Renewosome™ technology concentrates signaling vesicles sourced from human platelets — the same biological pathway the body uses for its own repair signaling. Dr. Piazza recommends the line for patients who want a clinically credible, research-backed exosome option with a pedigree traceable to a Mayo Clinic-affiliated research team, not just a trend ingredient.

Featured Product: Plated Intense Growth Factor Serum
Our top-selling Plated formula — concentrated Renewosome™ exosomes plus growth factors for patients focused on visible texture and tone improvement.

"Plated gives my patients access to platelet-derived exosome science with real research backing it — not just marketing. It's become one of our most trusted post-procedure and maintenance lines."

— Dr. Rocco Piazza, MD, FACS

Regulatory Notice: There are currently no FDA-approved exosome products for cosmetic indications. Plated products are intended for topical cosmetic use only and are not intended to diagnose, treat, cure, or prevent any medical condition.

PLATED-BY-RION-EXOSOMES-Collection-Page The Piazza Center for Plastic Surgery & Advanced Skincare

Best Exosomes for Anti-Aging

Plated™ Exosomes for Fine Lines & Wrinkles

Platelet-derived exosome skincare by Plated™. Learn how exosomes support smoother texture, improved radiance, and the look of firmer skin—plus how Plated™ compares to non-platelet exosomes.

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Exosome Skincare FAQs

What are exosomes in skincare?

Exosomes are tiny lipid vesicles that carry signaling molecules (proteins, RNAs, growth factors). In skincare, they help support cell-to-cell communication for a healthier-looking complexion.

How are Plated™ exosomes different?

Plated™ uses platelet-derived exosomes. Many exosome products use plant or yeast sources; Plated™ focuses on platelet origin—the body’s native carrier of skin-relevant growth factors.

Who benefits most from exosome skincare?

Anyone targeting visible signs of aging—fine lines, dullness, uneven tone—or looking to support post-procedure skin (follow your provider’s after-care instructions).

How do I layer exosomes with vitamin C or retinoids?

Apply exosome serum to clean skin, then targeted treatments (vitamin C AM, retinoid PM), moisturizer, and SPF in the morning. If irritation occurs, alternate days for actives.

How soon will I see results?

Radiance and texture can improve within weeks; the look of lines and firmness typically improves with consistent use over several weeks to months. Results vary.

Is this safe during pregnancy or breastfeeding?

Data for advanced actives is limited. If you’re pregnant or breastfeeding, consult your physician before use.