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INVO Aesthetics

INVO Rejuvenating Complex Exosome Serum, 30 mL

INVO Rejuvenating Complex Exosome Serum, 30 mL

Regular price $285.00
Regular price Sale price $285.00
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★★★★★★★★★★ 5.0 · 2 reviews
Dr. Rocco C. Piazza, MD, FACS, board-certified plastic surgeon

Why we replaced Plated with INVO

Dr. Rocco C. Piazza

Board-Certified Plastic Surgeon

“Plated served our patients well. But when I compared them side by side, INVO gave us three exosome sources instead of one, twice the serum, and vitamin C and peptides built in. When something better comes along, I owe it to my patients to make the switch.”

Learn more about Dr. Piazza →

The Plated INTENSE alternative.

Looking for a Plated INTENSE alternative? INVO Rejuvenating Complex is the exosome serum Dr. Piazza now stocks in its place, and the one he recommends when patients ask which exosome serum to use. It takes the place of several bottles: an exosome serum, a vitamin C and a peptide serum, all in one step, morning and night.

INVO vs Plated INTENSE

  • Three exosome sources (fibroblast, umbilical cord and bone marrow) instead of one
  • 30 mL instead of 15 mL: about $9.50 per mL vs about $17
  • Vitamin C and a peptide complex built in, so you don't need separate serums for either

What's in the bottle

  • 1.2+ trillion exosomes from three cell sources: fibroblast, umbilical cord and bone marrow
  • 1,200+ growth factors, proteins and peptides
  • Vitamin C and a peptide complex, so you don't need separate serums for either
  • BioBlend Technology™
  • 30 mL, twice the size of most exosome serums

What it does

  • Supports the production of new, healthy collagen and elastin
  • Visibly smooths fine lines and wrinkles for a radiant complexion
  • Contains antioxidants to support skin's natural defense against environmental stressors
  • Helps calm and soothe the skin, reducing the appearance of redness

Switching from Plated INTENSE

Finish the bottle you have, then move straight to INVO. There is no gap needed between the two.

Before and after treatment

Gentle enough for post-procedure skin. After microneedling, it's one of the best times to apply it. After a laser treatment, start once your provider clears you, and follow their timing.

How to use

Apply a few drops to clean, dry skin on the face and neck, morning and night, before your moisturizer. In the morning, follow with sunscreen. If you use a retinoid, apply the serum first. Give it eight weeks of twice-daily use.

Patient pricing

Patients of The Piazza Center receive clinic-exclusive pricing. Call the clinic to order at your patient rate.

Comparison based on published product information at retail price. Individual results vary.

Questions, answered

Is this replacing Plated INTENSE, and what do I do with the bottle I have?

Yes — INVO Rejuvenating Complex is the exosome serum we now stock in place of Plated INTENSE. Finish the bottle you have; there is no reason to throw out a good product, and nothing about switching requires a gap. When you are running low, this is what we would put you on next. The short version of why: three exosome sources rather than one, thirty millilitres rather than fifteen, and vitamin C and peptides already in the formula.

Where does this sit in my routine, and is it safe after a procedure?

Clean, dry skin, morning and night, before your moisturizer. In the morning, finish with sunscreen. If you use a retinoid, this goes on first. After microneedling it is one of the better times to apply it; after a laser treatment, start once your provider clears you and follow the timing they give you for your treatment depth. Give it eight weeks of twice-daily use before you judge it, and stay on it if you like what you see.

Why is this $285 when other exosome serums cost less?

Worth being straight about the math. At thirty millilitres this works out around $9.50 per millilitre; a fifteen-millilitre bottle at $258 is closer to $17. So the bottle price is higher and the cost of using it is meaningfully lower. It also carries vitamin C and a peptide complex, which for most people removes two other bottles from the shelf. What it is not is a more concentrated serum — per millilitre, some single-source serums are denser. You are buying sources, volume and the fewer steps.

Is it made from human cells?

Partly, and it is a fair thing to ask. There are no living cells in the bottle. Cells are grown in a laboratory, and what those cells release into the fluid around them is collected — the messengers, not the cells themselves. The sources are fibroblast, umbilical cord and bone marrow. If that is not something you are comfortable with, say so and we will walk you through a non-human option instead; that is a reasonable preference and not one we will argue you out of.

How long before I see anything?

Eight weeks, used twice a day. That is the honest answer and it is the commitment the product asks for. Most people notice the skin reflecting light more evenly before they notice anything about fine lines. Be clear-eyed about the ceiling too: a serum supports the look and feel of the skin, and it is not a substitute for a procedure. Deep folds, loose skin and volume loss are a different conversation, and we would rather have it with you than sell you a bottle instead.

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Where this sits in your protocol

Tested & endorsed by Dr. Piazza
  1. Pre-Procedure PrepUse it here
  2. Immediately Post-Procedure (day 0-1)
  3. Post-Procedure (day 2 onward)Use it here
  4. Recovery (1-4 weeks)Use it here
  5. Daily MaintenanceUse it here

What it targets

  • Fine Lines & Wrinkles
  • Post-Procedure Recovery
  • Dryness & Barrier Repair
  • Redness & Rosacea

Key actives

  • Exosomes
  • Growth Factors
  • Peptides
  • Vitamin C
  • Niacinamide

Is this the right one for you?

Both are good products. They do different jobs — here is the honest split.

  • You are here

    INVO Rejuvenating Complex Exosome Serum

    Three exosome sources, plus vitamin C and peptides in one bottle. One serum instead of three, morning and night.

    $285.00

  • Pavise Bioadaptive Stress Repair

    A nightly biostimulator aimed at firmness and tone over months. Evening only, so it pairs with whatever you already use in the morning.

    $228.00

    See Pavise Bioadaptive Stress Repair
  • EXO ELITE™ Skin Longevity Serum

    The light serum that goes on before your moisturizer — exosomes with copper peptide and hyaluronic acid.

    $224.00

    See EXO ELITE™ Skin Longevity Serum

Still not sure? Call the clinic on 737-787-7338 and we will tell you which one we would put you on.

Dr. Piazza talking with female patient

The Piazza Protocols

Hand-selected by board-certified plastic surgeon Dr. Rocco Piazza, MD, FACS, to meet the highest standards in medical-grade skincare.

🛡️ Board-Certified Plastic Surgeon
🔬 Backed by Clinical Expertise & Research

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