INVO Aesthetics
INVO Rejuvenating Complex Exosome Serum, 30 mL
INVO Rejuvenating Complex Exosome Serum, 30 mL
“Plated served our patients well, and I’m not here to trash it. INVO earned its place because it does more in one step: three engineered cargo sources — umbilical, bone marrow and fibroblast — plus vitamin C and growth factors, in a bottle twice the size. It’s a true workhorse.”
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Less is more.
INVO Rejuvenating Complex is the serum Dr. Piazza now recommends when patients ask which exosome serum to use. It takes the place of several bottles: an exosome serum, a vitamin C and a peptide serum, all in one step, morning and night.
What's in the bottle
- 1.2+ trillion exosomes from three cell sources: fibroblast, umbilical cord and bone marrow
- 1,200+ growth factors, proteins and peptides
- Vitamin C and a peptide complex, so you don't need separate serums for either
- BioBlend Technology™
- 30 mL, twice the size of most exosome serums
What it does
- Supports the production of new, healthy collagen and elastin
- Visibly smooths fine lines and wrinkles for a radiant complexion
- Contains antioxidants to support skin's natural defense against environmental stressors
- Helps calm and soothe the skin, reducing the appearance of redness
Before and after treatment
Gentle enough for post-procedure skin. After microneedling, it's one of the best times to apply it. After a laser treatment, start once your provider clears you, and follow their timing.
How to use
Apply a few drops to clean, dry skin on the face and neck, morning and night, before your moisturizer. In the morning, follow with sunscreen. If you use a retinoid, apply the serum first. Give it eight weeks of twice-daily use.
Why we made the switch
"Plated served our patients well. But when I compared them side by side, INVO gave us three exosome sources instead of one, twice the serum, and vitamin C and peptides built in. When something better comes along, I owe it to my patients to make the switch."
Dr. Rocco C. Piazza II, MD, FACS
Patient pricing
Patients of The Piazza Center receive clinic-exclusive pricing. Call the clinic to order at your patient rate.
Individual results vary.
Questions, answered
Is this replacing Plated INTENSE, and what do I do with the bottle I have?
Is this replacing Plated INTENSE, and what do I do with the bottle I have?
Where does this sit in my routine, and is it safe after a procedure?
Where does this sit in my routine, and is it safe after a procedure?
Why is this $285 when other exosome serums cost less?
Why is this $285 when other exosome serums cost less?
Is it made from human cells?
Is it made from human cells?
How long before I see anything?
How long before I see anything?
Questions, answered
Is this replacing Plated INTENSE, and what do I do with the bottle I have?
Is this replacing Plated INTENSE, and what do I do with the bottle I have?
Where does this sit in my routine, and is it safe after a procedure?
Where does this sit in my routine, and is it safe after a procedure?
Why is this $285 when other exosome serums cost less?
Why is this $285 when other exosome serums cost less?
Is it made from human cells?
Is it made from human cells?
How long before I see anything?
How long before I see anything?

The Piazza Protocols
Hand-selected by board-certified plastic surgeon Dr. Rocco Piazza, MD, FACS, to meet the highest standards in medical-grade skincare.
🛡️ Board-Certified Plastic Surgeon
🔬 Backed by Clinical Expertise & Research
Advanced Retinol Protocol
Reduce fine lines and improve skin texture through medical-grade retinoid therapy.
Brightening Complex Protocol
Target dark spots and uneven tone with clinical-strength brightening agents.
Clinical Acne Control Protocol
Clear active breakouts and prevent future acne with medical-grade formulations.
Advanced Retinol Protocol
Skin Preparation
Begin with gentle cleanser and barrier repair serum to prepare skin for active treatment.
Retinol Introduction
Introduce 0.25% retinol 2-3 times per week, monitoring for tolerance.
Gradual Increase
Increase frequency to nightly application as tolerated.
Strength Advancement
Progress to 0.5% retinol formulation for enhanced results.
Maintenance Phase
Continue nightly application with quarterly clinical assessments.
Brightening Complex Protocol
Assessment & Prep
Clinical photography and baseline assessment with gentle exfoliation.
Active Treatment
Apply brightening serum with hydroquinone alternative twice daily.
Enhancement Phase
Add vitamin C serum in morning routine for synergistic effects.
Progress Evaluation
Clinical reassessment and protocol adjustment as needed.
Long-term Maintenance
Continue maintenance regimen with SPF 50+ daily protection.
Clinical Acne Control Protocol
Barrier Restoration
Gentle cleansing and barrier support to prepare for active treatment.
Benzoyl Peroxide Introduction
Begin 2.5% benzoyl peroxide application every other evening.
Salicylic Acid Addition
Add 2% salicylic acid serum in morning routine for pore refinement.
Retinoid Integration
Introduce retinoid 2-3 times weekly for enhanced cell turnover.
Maintenance & Prevention
Continue full protocol with monthly clinical monitoring.
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