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INVO Aesthetics

INVO Rejuvenating Complex Exosome Serum, 30 mL

INVO Rejuvenating Complex Exosome Serum, 30 mL

Regular price $285.00
Regular price Sale price $285.00
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Dr. P

Why we replaced Plated with INVO

Dr. Rocco C. Piazza

Board-Certified Plastic Surgeon

“Plated served our patients well, and I’m not here to trash it. INVO earned its place because it does more in one step: three engineered cargo sources — umbilical, bone marrow and fibroblast — plus vitamin C and growth factors, in a bottle twice the size. It’s a true workhorse.”

Learn more about Dr. Piazza →

Less is more.

INVO Rejuvenating Complex is the serum Dr. Piazza now recommends when patients ask which exosome serum to use. It takes the place of several bottles: an exosome serum, a vitamin C and a peptide serum, all in one step, morning and night.

What's in the bottle

  • 1.2+ trillion exosomes from three cell sources: fibroblast, umbilical cord and bone marrow
  • 1,200+ growth factors, proteins and peptides
  • Vitamin C and a peptide complex, so you don't need separate serums for either
  • BioBlend Technology™
  • 30 mL, twice the size of most exosome serums

What it does

  • Supports the production of new, healthy collagen and elastin
  • Visibly smooths fine lines and wrinkles for a radiant complexion
  • Contains antioxidants to support skin's natural defense against environmental stressors
  • Helps calm and soothe the skin, reducing the appearance of redness

Before and after treatment

Gentle enough for post-procedure skin. After microneedling, it's one of the best times to apply it. After a laser treatment, start once your provider clears you, and follow their timing.

How to use

Apply a few drops to clean, dry skin on the face and neck, morning and night, before your moisturizer. In the morning, follow with sunscreen. If you use a retinoid, apply the serum first. Give it eight weeks of twice-daily use.

Why we made the switch

"Plated served our patients well. But when I compared them side by side, INVO gave us three exosome sources instead of one, twice the serum, and vitamin C and peptides built in. When something better comes along, I owe it to my patients to make the switch."

Dr. Rocco C. Piazza II, MD, FACS

Patient pricing

Patients of The Piazza Center receive clinic-exclusive pricing. Call the clinic to order at your patient rate.

Individual results vary.

Questions, answered

Is this replacing Plated INTENSE, and what do I do with the bottle I have?

Yes — INVO Rejuvenating Complex is the exosome serum we now stock in place of Plated INTENSE. Finish the bottle you have; there is no reason to throw out a good product, and nothing about switching requires a gap. When you are running low, this is what we would put you on next. The short version of why: three exosome sources rather than one, thirty millilitres rather than fifteen, and vitamin C and peptides already in the formula.

Where does this sit in my routine, and is it safe after a procedure?

Clean, dry skin, morning and night, before your moisturizer. In the morning, finish with sunscreen. If you use a retinoid, this goes on first. After microneedling it is one of the better times to apply it; after a laser treatment, start once your provider clears you and follow the timing they give you for your treatment depth. Give it eight weeks of twice-daily use before you judge it, and stay on it if you like what you see.

Why is this $285 when other exosome serums cost less?

Worth being straight about the math. At thirty millilitres this works out around $9.50 per millilitre; a fifteen-millilitre bottle at $258 is closer to $17. So the bottle price is higher and the cost of using it is meaningfully lower. It also carries vitamin C and a peptide complex, which for most people removes two other bottles from the shelf. What it is not is a more concentrated serum — per millilitre, some single-source serums are denser. You are buying sources, volume and the fewer steps.

Is it made from human cells?

Partly, and it is a fair thing to ask. There are no living cells in the bottle. Cells are grown in a laboratory, and what those cells release into the fluid around them is collected — the messengers, not the cells themselves. The sources are fibroblast, umbilical cord and bone marrow. If that is not something you are comfortable with, say so and we will walk you through a non-human option instead; that is a reasonable preference and not one we will argue you out of.

How long before I see anything?

Eight weeks, used twice a day. That is the honest answer and it is the commitment the product asks for. Most people notice the skin reflecting light more evenly before they notice anything about fine lines. Be clear-eyed about the ceiling too: a serum supports the look and feel of the skin, and it is not a substitute for a procedure. Deep folds, loose skin and volume loss are a different conversation, and we would rather have it with you than sell you a bottle instead.

Questions, answered

Is this replacing Plated INTENSE, and what do I do with the bottle I have?

Yes — INVO Rejuvenating Complex is the exosome serum we now stock in place of Plated INTENSE. Finish the bottle you have; there is no reason to throw out a good product, and nothing about switching requires a gap. When you are running low, this is what we would put you on next. The short version of why: three exosome sources rather than one, thirty millilitres rather than fifteen, and vitamin C and peptides already in the formula.

Where does this sit in my routine, and is it safe after a procedure?

Clean, dry skin, morning and night, before your moisturizer. In the morning, finish with sunscreen. If you use a retinoid, this goes on first. After microneedling it is one of the better times to apply it; after a laser treatment, start once your provider clears you and follow the timing they give you for your treatment depth. Give it eight weeks of twice-daily use before you judge it, and stay on it if you like what you see.

Why is this $285 when other exosome serums cost less?

Worth being straight about the math. At thirty millilitres this works out around $9.50 per millilitre; a fifteen-millilitre bottle at $258 is closer to $17. So the bottle price is higher and the cost of using it is meaningfully lower. It also carries vitamin C and a peptide complex, which for most people removes two other bottles from the shelf. What it is not is a more concentrated serum — per millilitre, some single-source serums are denser. You are buying sources, volume and the fewer steps.

Is it made from human cells?

Partly, and it is a fair thing to ask. There are no living cells in the bottle. Cells are grown in a laboratory, and what those cells release into the fluid around them is collected — the messengers, not the cells themselves. The sources are fibroblast, umbilical cord and bone marrow. If that is not something you are comfortable with, say so and we will walk you through a non-human option instead; that is a reasonable preference and not one we will argue you out of.

How long before I see anything?

Eight weeks, used twice a day. That is the honest answer and it is the commitment the product asks for. Most people notice the skin reflecting light more evenly before they notice anything about fine lines. Be clear-eyed about the ceiling too: a serum supports the look and feel of the skin, and it is not a substitute for a procedure. Deep folds, loose skin and volume loss are a different conversation, and we would rather have it with you than sell you a bottle instead.

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Dr. Piazza talking with female patient

The Piazza Protocols

Hand-selected by board-certified plastic surgeon Dr. Rocco Piazza, MD, FACS, to meet the highest standards in medical-grade skincare.

🛡️ Board-Certified Plastic Surgeon
🔬 Backed by Clinical Expertise & Research

DISCOVER OUR PHILOSOPHY
Anti-Aging

Advanced Retinol Protocol

Reduce fine lines and improve skin texture through medical-grade retinoid therapy.

Hyperpigmentation

Brightening Complex Protocol

Target dark spots and uneven tone with clinical-strength brightening agents.

Acne Management

Clinical Acne Control Protocol

Clear active breakouts and prevent future acne with medical-grade formulations.

Verified by Dr. Piazza

Advanced Retinol Protocol

Week 1-2

Skin Preparation

Begin with gentle cleanser and barrier repair serum to prepare skin for active treatment.

Week 3-4

Retinol Introduction

Introduce 0.25% retinol 2-3 times per week, monitoring for tolerance.

Week 5-8

Gradual Increase

Increase frequency to nightly application as tolerated.

Week 9-12

Strength Advancement

Progress to 0.5% retinol formulation for enhanced results.

Week 12+

Maintenance Phase

Continue nightly application with quarterly clinical assessments.

Brightening Complex Protocol

Week 1-2

Assessment & Prep

Clinical photography and baseline assessment with gentle exfoliation.

Week 3-6

Active Treatment

Apply brightening serum with hydroquinone alternative twice daily.

Week 7-10

Enhancement Phase

Add vitamin C serum in morning routine for synergistic effects.

Week 11-12

Progress Evaluation

Clinical reassessment and protocol adjustment as needed.

Week 12+

Long-term Maintenance

Continue maintenance regimen with SPF 50+ daily protection.

Clinical Acne Control Protocol

Week 1-2

Barrier Restoration

Gentle cleansing and barrier support to prepare for active treatment.

Week 3-4

Benzoyl Peroxide Introduction

Begin 2.5% benzoyl peroxide application every other evening.

Week 5-8

Salicylic Acid Addition

Add 2% salicylic acid serum in morning routine for pore refinement.

Week 9-12

Retinoid Integration

Introduce retinoid 2-3 times weekly for enhanced cell turnover.

Week 12+

Maintenance & Prevention

Continue full protocol with monthly clinical monitoring.