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Exoceuticals

EXO PLUS® Anti-Aging Cream

EXO PLUS® Anti-Aging Cream

Regular price $136.50
Regular price $195.00 Sale price $136.50
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Dr. P

Selected by an Expert

Dr. Rocco C. Piazza

Board-Certified Plastic Surgeon

“My goal is to provide my patients with the highest quality, scientifically-backed solutions to support their wellness journey. Each product is formulated with that same commitment to excellence and efficacy.”

Learn more about Dr. Piazza →
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KEY INGREDIENTS

eXo³ Exosomes
At the heart of EXO PLUS™ is its proprietary eXo³ Exosome Technology. These bioactive nanoparticles are derived from stem cells and engineered to deliver targeted repair and rejuvenation. They:

  • Stimulate collagen production and fibroblast proliferation to reduce fine lines and wrinkles

  • Modulate inflammatory responses to calm redness and irritation

  • Deliver essential lipids, growth factors, nucleic acids, and proteins to nourish and reinforce skin barrier function

Hyaluronic Acid
Multi-molecular weights deliver instant and long-term hydration, plump fine lines, and boost natural hyaluronic acid production.

Collagen-Building Peptides & Proteins
Support dermal matrix strength and elasticity while improving skin tone and texture.

Retinyl Palmitate (Provitamin A) 
A gentler, stabilized retinol derivative that:

  • Promotes skin cell turnover and smoothness

  • Diminishes wrinkles and improves texture

  • Helps fade hyperpigmentation and blemishes

  • Provides antioxidant protection

Essential Fatty Acids
A skin-restoring complex of Omegas 3, 6, 7, and 9 that:

  • Rebuild ceramides and support the lipid barrier

  • Improve elasticity and suppleness

  • Provide anti-inflammatory and antibacterial benefits

ESS Vitamin Complex (A, C, D3, E)
A powerhouse of antioxidants and skin-renewing vitamins that:

  • Boost collagen synthesis

  • Brighten skin tone and reduce dark spots

  • Protect against oxidative stress

  • Strengthen the skin’s immune defense

Coconut Oil
Deeply hydrates and soothes with natural antimicrobial and anti-inflammatory properties.

Grape Seed Oil
Rich in linoleic acid and antioxidants to improve elasticity, reduce inflammation, and support a clear complexion.

Brown Algae Extract (BAE)
Delivers potent antioxidant and UV-protective benefits while enhancing hydration and oxygenation for youthful glow.

Botanical Super Extracts
Including Noni Fruit and Agastache Mexicana, these plant actives soothe irritation, calm inflammation, and promote microbiome balance.

CCT & OM Fatty Acids
Nourish and fortify the skin’s protective barrier without clogging pores—ideal for all skin types.

TEXTURE
  • Rich, yet smooth and weightless, this cream melts seamlessly into the skin, leaving it soft, hydrated, and perfectly prepped. The silky texture wears beautifully alone or as a base under skincare and makeup.
INGREDIENTS LIST

Water, Cocos Nucifera (Coconut) Oil, Caprylic/Capric Triglyceride (Fatty Acid), Octyldodecyl Myristate (Fatty Acid), Dimethicone, Glycerin, PEG-8 Beeswax, Human Adipose Stromal Cell Exosomes (exo3 Exosomes), Vitis Vinifera (Grape) Seed Oil, Macadamia Ternifolia Seed Oil, Eucalyptus Globulus Leaf Oil, Acrylates/Acrylamide Copolymer, Mineral Oil, Polysorbate 85, Cetyl Alcohol, Ceteth-20, Steareth-20, Phenoxyethanol, Propanediol, Glyceryl Monostearate, Allantoin, Citric Acid, Morinda Citrifolia (Noni) Fruit Juice, Agastache Mexicana Flower/Leaf/Stem Extract, Algae Extract (Sea Kelp), Chondrus Crispus Extract (Irish Sea Moss), Ulva Lactuca Extract (Sea Lettuce) , Undaria Pinnatifida Extract (Japanese Wakame), Laminaria Digitata Extract (Brown Algae), Sodium Hyaluronate, Ascorbic Acid (Vitamin C), Retinyl Palmitate (Vitamin A), Tocopheryl Acetate (Vitamin E), Cholecalciferol (Vitamin D3)

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Dr. Piazza talking with female patient

The Piazza Protocols

Hand-selected by board-certified plastic surgeon Dr. Rocco Piazza, MD, FACS, to meet the highest standards in medical-grade skincare.

🛡️ Board-Certified Plastic Surgeon
🔬 Backed by Clinical Expertise & Research

DISCOVER OUR PHILOSOPHY
Anti-Aging

Advanced Retinol Protocol

Reduce fine lines and improve skin texture through medical-grade retinoid therapy.

Hyperpigmentation

Brightening Complex Protocol

Target dark spots and uneven tone with clinical-strength brightening agents.

Acne Management

Clinical Acne Control Protocol

Clear active breakouts and prevent future acne with medical-grade formulations.

Verified by Dr. Piazza

Advanced Retinol Protocol

Week 1-2

Skin Preparation

Begin with gentle cleanser and barrier repair serum to prepare skin for active treatment.

Week 3-4

Retinol Introduction

Introduce 0.25% retinol 2-3 times per week, monitoring for tolerance.

Week 5-8

Gradual Increase

Increase frequency to nightly application as tolerated.

Week 9-12

Strength Advancement

Progress to 0.5% retinol formulation for enhanced results.

Week 12+

Maintenance Phase

Continue nightly application with quarterly clinical assessments.

Brightening Complex Protocol

Week 1-2

Assessment & Prep

Clinical photography and baseline assessment with gentle exfoliation.

Week 3-6

Active Treatment

Apply brightening serum with hydroquinone alternative twice daily.

Week 7-10

Enhancement Phase

Add vitamin C serum in morning routine for synergistic effects.

Week 11-12

Progress Evaluation

Clinical reassessment and protocol adjustment as needed.

Week 12+

Long-term Maintenance

Continue maintenance regimen with SPF 50+ daily protection.

Clinical Acne Control Protocol

Week 1-2

Barrier Restoration

Gentle cleansing and barrier support to prepare for active treatment.

Week 3-4

Benzoyl Peroxide Introduction

Begin 2.5% benzoyl peroxide application every other evening.

Week 5-8

Salicylic Acid Addition

Add 2% salicylic acid serum in morning routine for pore refinement.

Week 9-12

Retinoid Integration

Introduce retinoid 2-3 times weekly for enhanced cell turnover.

Week 12+

Maintenance & Prevention

Continue full protocol with monthly clinical monitoring.