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Exoceuticals

EXO ELITE™ Skin Longevity Serum

EXO ELITE™ Skin Longevity Serum

Regular price $224.00
Regular price Sale price $224.00
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Dr. Rocco C. Piazza, MD, FACS, board-certified plastic surgeon

Selected by an Expert

Dr. Rocco C. Piazza

Board-Certified Plastic Surgeon

“My goal is to provide my patients with the highest quality, scientifically-backed solutions to support their wellness journey. Each product is formulated with that same commitment to excellence and efficacy.”

Learn more about Dr. Piazza →
DESCRIPTION ◄

EXO ELITE™ Skin-Longevity Serum includes key ingredients that support nighttime skin repair and cell rejuvenation by enhancing skin hydration, aiding in cell turnover, collagen production, and strengthening the skin’s barrier.

Your skin works overtime while you sleep, making this the ideal time to nourish it with powerful repair ingredients—revealing visibly stronger, more luminous skin by morning.

Nighttime Benefits:

  • Deep, sustained hydration across all skin layers overnight
  • Supports collagen and elastin renewal during sleep
  • Helps repair barrier damage caused by daily stress and dehydration
  • Skin appears smoother, firmer, and more rested by morning
BENEFITS ◄
  • Restores skin balance and hydration
  • Visibly reduces the appearance of fine lines and wrinkles
  • Improves skin density and firmness, addressing sagging
  • Replenishes skin for a smoother, more radiant complexion
  • Supports long-term skin health and resilience
  • Promotes even tone and refined texture
  • Renews the look and feel of aging or stressed skin
SUITABLE FOR ◄
  • Sensitive Skin
  • Dry or Dehydrated Skin
  • Damaged or Stressed Skin
  • Aging / Mature Skin
TEXTURE ◄
  • A lightweight, fast-absorbing hydrating serum that glides smoothly and absorbs quickly without residue — ideal for layering with moisturizers or other treatments.
HOW TO USE ◄
  • Apply 3–5 drops to face, neck, and décolleté.
  • Gently press and pat until fully absorbed.
  • Follow with EXO Elevate™ Skin Longevity Complex or your moisturizer of choice.
  • Use AM + PM.
KEY INGREDIENTS ◄
  • eXo³ Exosomes — Potent Cellular Signaling
    Engineered nanoparticles that deliver bioactive proteins, peptides, growth factors, lipids, and nucleic acids directly to target cells.
    They help:
    • Improve collagen and elastin production
    • Stimulate skin regeneration
    • Accelerate cell turnover
    • Support immune balance
    • Increase hydration
  • Hyaluronic Acid Complex — Seven Molecular Weights
    A multi-weight HA system that penetrates through all layers of skin, not just the surface.
    Benefits include:
    • Deep and lasting hydration
    • Restored elasticity from within
    • Three-dimensional moisture network for youthful plumpness
    • Improved resilience and bounce
    • Slows visible signs of aging and damage
  • Copper Tripeptide (GHK-Cu)
    A powerful longevity peptide naturally found in the body, replenished here at optimal levels.
    Supports:
    • Collagen + elastin production (firmer skin)
    • Reduced wrinkles
    • Reduced hyperpigmentation
    • Calming of redness + irritation
    • Stronger skin barrier
    • Improved texture
    • Enhanced regeneration
  • Aloe Vera
    Soothing, hydrating, and restorative — supports calm, balanced skin and improved moisture retention.
  • Next Gen Naturals™ — Marine-Derived Complex
    A proprietary blend of nutrient-rich sea ingredients known to support skin longevity. Includes:
    • Algae Extract
    • Chondrus Crispus (Irish Moss)
    • Undaria Pinnatifida Extract
    • Laminaria Digitata (Brown Algae)
    • Ulva Lactuca (Sea Lettuce)
    This complex nourishes, hydrates, and strengthens the skin’s barrier while delivering antioxidant protection.
  • Noni (Morinda Citrifolia)
    A powerful antioxidant rich in vitamins and phytonutrients.
    Helps:
    • Calm irritation
    • Support healing
    • Improve tone and elasticity
  • Vitamins A, D, E — Essential Skin Nutrients
    Support cellular renewal, provide antioxidant protection, strengthen the skin barrier, improve texture, and enhance overall resilience.
FULL INGREDIENTS LIST ◄

Water, Methyl Gluceth-20, Bis-PEG-18 Methyl Ether Dimethyl Silane, Sodium Hyaluronate, Sodium Acetylated Hyaluronate, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Human Adipose Stromal Cell Exosome, Sclerotium Gum, Copper Tripeptide-1, Aloe Barbadensis Leaf Extract, Allantoin, Cholecalciferol, Retinyl Palmitate, Morinda Citrifolia Fruit Juice, Tocopheryl Acetate, Phytic Acid, Glycerin, Algae Extract, Chondrus Crispus Extract, Propanediol, Agastache Mexicana Flower/Leaf/Stem Extract, Undaria Pinnatifida Extract, Laminaria Digitata Extract, Ulva Lactuca Extract, Citric Acid, Sodium Hydroxide, Caprylyl Glycol, Hexylene Glycol, Phenoxyethanol, Ethylhexylglycerin.

Questions, answered

What does an exosome serum do that a good peptide serum doesn't?

Exosomes are signalling vesicles — carriers that hold growth factors and other messengers. The proposition is that instead of supplying one active, you are supplying instructions. A peptide is a single message; an exosome preparation carries many. That is the theory, and it is a reasonable one. What we tell patients is that the strongest human evidence for exosomes comes from applying them through a channel — immediately after microneedling or fractional laser, when the barrier is open — rather than onto intact skin. On intact skin, treat this as maintenance between visits.

ELITE at night and ELEVATE in the morning, or both twice a day?

ELITE is the night serum, ELEVATE is the daily cream. The straightforward version: ELITE on clean skin at night, ELEVATE over it; in the morning, ELEVATE and then SPF. You do not need ELITE twice a day, and using it that way mostly means reordering twice as often. If you only want one, take ELEVATE — it is the recommended daily foundation of the range and the one to build on.

$224 for a serum. Is the exosome science actually there yet?

Where we are most confident is the setting we use them in: immediately after microneedling or fractional laser, while the channels are open. That is where the human evidence is strongest, and it is why exosomes are a defined step in the Piazza protocols rather than an add-on we sell. On intact skin the case is more modest — the mechanism is well described and the early data encouraging — so we call at-home use maintenance between visits rather than a replacement for in-office delivery. That is what this bottle is for. Build on a retinoid and daily mineral SPF first; this sits on top of that foundation.

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Where this sits in your protocol

Tested & endorsed by Dr. Piazza
  1. Pre-Procedure Prep
  2. Immediately Post-Procedure (day 0-1)
  3. Post-Procedure (day 2 onward)
  4. Recovery (1-4 weeks)
  5. Daily MaintenanceUse it here

What it targets

  • Fine Lines & Wrinkles
  • Laxity & Volume Loss

Key actives

  • Exosomes
  • Peptides

Is this the right one for you?

Both are good products. They do different jobs — here is the honest split.

  • You are here

    EXO ELITE™ Skin Longevity Serum

    The light serum that goes on before your moisturizer — exosomes with copper peptide and hyaluronic acid.

    $224.00

  • INVO Rejuvenating Complex Exosome Serum

    Three exosome sources, plus vitamin C and peptides in one bottle. One serum instead of three, morning and night.

    $285.00

    See INVO Rejuvenating Complex Exosome Serum

Still not sure? Call the clinic on 737-787-7338 and we will tell you which one we would put you on.

Dr. Piazza talking with female patient

The Piazza Protocols

Hand-selected by board-certified plastic surgeon Dr. Rocco Piazza, MD, FACS, to meet the highest standards in medical-grade skincare.

🛡️ Board-Certified Plastic Surgeon
🔬 Backed by Clinical Expertise & Research

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